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Confocal microscopic image of the infection of a wheat plant: the fungus penetrates the stomata of the leaves and can spread between the plant cells.

Photo courtesy:
J. Haueisen, Stukenbrock lab

Two pipefish females of the species Syngnathus typhle.

Photo courtesy:
Olivia Roth

The fluorescent dye DAPI is commonly used to stain the DNA in the nuclei of Caenorhabditis elegans body cells, thus visualizing the nematode’s anatomy.

Photo courtesy:
Hinrich Schulenburg

Confocal laser scanning microscopy image of the fungal pathogen Zymoseptoria tritici (in green) during the infection of a wheat leaf. The hyphae of Z. tritici is visible in green.

Photo courtesy:
J. Haueisen, Stukenbrock lab

The brood pouch of a pregnant pipefish male (Syngnathus typhle) filled with embryos that are connected to a placenta-like structure.

Photo courtesy:
Olivia Roth

Pathogenic Bacillus thuringiensis bacteria marked by Red Fluorescent Protein have infected and overgrown the body of a Caenorhabditis elegans nematode.

Photo courtesy:
Andrei Papkou, Schulenburg lab

A wheat leaf infested with the fungus Zymoseptoria tritici shows the typical signs of so-called leaf drought, which can lead to drastic crop failures.

Photo courtesy:
J. Haueisen, Stukenbrock lab

Publications

2021

Basu M*, Philipp L*, Sebens S & Baines JF (in press): 
The microbiome tumor axis: how the microbiome could contribute to clonal heterogeneity and disease outcome in pancreatic cancer.
Frontiers in Oncology, in press. *shared first authorship

Batra A*, Roemhild R*, Rousseau E, Franzenburg S, Niemann S & Schulenburg H (2021): 
High potency of sequential therapy with only beta-lactam antibiotics.
eLife 2021; 10:e68876. *shared first authorship

Raatz M, Shah S, Chitadze G, Brüggemann M & Traulsen A (2021):
The impact of phenotypic heterogeneity of tumour cells on treatment and relapse dynamics.
PLoS Computational Biology 17(2): e1008702.

Reusch TBH, Baums IB & Werner B (in press): 
Evolution via somatic genetic variation in modular species.
Trends in Ecology & Evolution, in press.

Wein T*, Wang Y*, Barz M, Stuecker F, Hammerschmidt K & Dagan T (2021): 
Essential gene acquisition destabilizes plasmid inheritance.
PLoS Genetics 17(7): e1009656. https://doi.org/10.1371/journal.pgen.1009656. *shared first authorship

2020

Ebert MK, Rangel LI, Spanner RE, Taliadoros D, Wang X, Friesen TL, de Jonge R, Neubauer JD, Secor GA, Thomma BPHJ, Stukenbrock EH & Boldton MD (2020): 
Identification an characterization of Cercospora beticola necrosis-inducing effector CbNip1. 
Molecular Plant Pathology 22: 301– 316.

Schenk H, Schulenburg H & Traulsen A (2020): 
How long do Red Queen dynamics survive under genetic drift? A comparative analysis of evolutionary and eco-evolutionary models.
BMC Ecology and Evolution 20, 8. 

Merker M, Tueffers L, Vallier M, Groth E, Sonnenkalb L, Unterweger D, Baines J, Niemann S, Schulenburg H (2020): 
Evolutionary approaches to combat antibiotic resistance: opportunities and challenges for precision medicine.
Frontiers in Immunolgy 11:1938. 

Haensel MC, Schmidt JO, Stiasny MH, Stoven M., Voss R & Quaas MF (2020): 
Ocean warming and acidification may drag down the commercial Arctic cod fishery by 2100.
PLoS ONE 15(4): e0231589. 

Hassani MA, Özkurt E, Franzenburg S, Stukenbrock EH (2020): 
Ecological assembly processes of the bacterial and fungal microbiota of wild and domesticated wheat species. 
Phytobiomes Journal

Heckwolf MJ, Meyer BS, Häsler R et al. (2020): 
Two different epigenetic information channels  in wild three-spined sticklebacks are involved in salinity adaptation. 
Science Advances 6:eaaz1138. 

Köster FW, Huwer B , Kraus G et al. (2020): 
Egg production methods applied to Eastern Baltic cod provide indices of spawning stock dynamics. 
Fisheries Research 227:105553.

Olivia Roth O,  Hongrø Solbakken M, Tørresen OK et al. (2020): 
Evolution of male pregnancy associated with remodeling of canonical vertebrate immunity in seahorses and pipefishes. 
Proceedings of the National Academy of Sciences USA 117 (17) 9431-9439.

Seybold H, Demetrowitsch TJ, Hassani MA et al. (2020): 
A fungal pathogen induces systemic susceptibility and systemic shifts in wheat metabolome and microbiome composition.
Nature Communications 11, 1910.

Szymczak S, Dose J, Torres GG, et al. (2020): 
DNA methylation QTL analysis identifies new regulators of human longevity.
Human Molecular Genetics, ddaa033. 

2019

Barbosa C*, Roemhild R*, Rosenstiel P, Schulenburg H (2019): 
Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa. 
eLife 8:e51481. *Shared first or senior authorship.

Fabian A, Stegner S, Miarka L et al. (2019): 
Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells. 
Cancer Letters 453:95-106.

Metcalf CJE, Roth O, Graham AL (2019): 
Why leveraging sex differences in immune trade-offs may illuminate the evolution of senescence. 
Functional Ecology 34, 129-140.      

Opasic L, Zhou D, Werner B, Dingli D, Traulsen A (2019): 
How many samples are needed to infer truly clonal mutations from heterogenous tumours? 
BMC Cancer 19, 403.

Quaas MF and Tahvonen O (2019): 
Strategic Harvesting of Age-Structured Populations.
Marine Resource Economics 34(4): 291-309.

Stiasny MH, Sswat M, Mittermayer FH et al. (2019): 
Divergent responses of Atlantic cod to ocean  acidification and food limitation. 
Global Change Biology 25:839-849.

Tueffers L, Barbosa C, Bobis I et al. (2019): 
Pseudomonas aeruginosa populations in the cystic fibrosis lung lose sensitivity to newly applied ß-lactam antibiotics within less than three days. 
Journal of Antimicrobial Chemotherapy 74:2916-2925.

Wein T, Hülter NF, Mizrahi I, Dagan T (2019): 
Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance. 
Nature Communications 10, 2595.

Zhou D, Luo Y, Dingli D, Traulsen A (2019): 
The invasion of de-differentiating cancer cells into hierarchical tissues. 
PLoS Computational Biology 15(7):e1007167. 

2018

Höft N, Dally N, Hasler M, Jung C (2018): 
Haplotype variation of flowering time genes of sugar beet and its wild relatives and the impact on life cycle regimes. 
Frontiers in Plant Science 8 (2211). 

Kupczok A, Neve H. Huang KD et al. (2018): 
Rates of mutation and recombination in Siphoviridae phage genome evolution over three decades. 
Molecular Biology and Evolution 35(5), 1147–1159.

Merker M, Barbier M, Cox H et al. (2018): 
Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia. 
eLife 30;7. pii: e38200.

2017

Ammerpohl O, Hattermann K, Held-Feindt J et al. (2017): 
Dormancy: an evolutionary key phenomenon in cancer development. 
In “Ecology and evolution of cancer”, ISBN: 978-0-12-804310-3

Beemelmanns A & Roth O (2017): 
Grandparental immune priming in the pipefish Syngnathus typhle. 
BMC Evolutionary Biology 17, 44.

Flachsbart F, Dose J, Gentschew L et al. (2017): 
Identification and characterization of two functional variants in the human longevity gene FOXO3. 
Nature Communications 8, 2063. 

van Ingen J, Kohl TA, Kranzer K et al. (2017): 
Global outbreak of severe Mycobacterium chimaera disease after cardiac surgery: a molecular epidemiological study. 
The Lancet Infectious Diseases 17(10):1033-1041. *equal contribution

2016

Stiasny MH, Mittermayer FH, Sswat M et al. (2016): 
Ocean Acidification Effects on Atlantic Cod Larval  Survival and Recruitment to the Fished Population. 
PLoS One 11:e0155448.